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Article

Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank.

Nature communications - 26 Aug 2024

Hillary Robert F, Gadd Danni A, Kuncheva Zhana, Mangelis Tasos, Lin Tinchi, Ferber Kyle, McLaughlin Helen, Runz Heiko, Marioni Riccardo E, Foley Christopher N, Sun Benjamin B

Abstract excerpt

Understanding how gene-environment interactions (GEIs) influence the circulating proteome could aid in biomarker discovery and validation. The presence of GEIs can be inferred from single nucleotide polymorphisms that associate with phenotypic variability - termed variance quantitative trait loci (vQTLs). Here, vQTL association studies are performed on plasma levels of 1463 proteins in 52,363 UK Biobank...

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Identifiers

PMID: 39187491
DOI: 10.1038/s41467-024-51744-5
PMCID: PMC11347662

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