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Article

Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers.

Nature communications - 9 Jul 2022

Westerman Kenneth E, Majarian Timothy D, Giulianini Franco, Jang Dong-Keun, Miao Jenkai, Florez Jose C, Chen Han, Chasman Daniel I, Udler Miriam S, Manning Alisa K, Cole Joanne B

Abstract excerpt

Gene-environment interactions represent the modification of genetic effects by environmental exposures and are critical for understanding disease and informing personalized medicine. These often induce differential phenotypic variance across genotypes; these variance-quantitative trait loci can be prioritized in a two-stage interaction detection strategy to greatly reduce the computational and statistical burden...

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Identifiers

PMID: 35810165
DOI: 10.1038/s41467-022-31625-5
PMCID: PMC9271055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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