Article

Interactions with polygenic background impact quantitative traits in the UK Biobank

2025-11-17

Abstract excerpt

Association studies have linked many genetic variants to a variety of phenotypes but understanding the biological mechanisms underlying these signals remains a major challenge. Since genes operate within complex networks, statistical interactions between genetic mutations that reflect biological pathways are expected to exist. However, their discovery has been hampered by the vast search space of variant combinati...

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Literature Corpus work: 9c7a0c5f-ff56-58d3-9333-bda8aafa9c22
DOI: 10.1101/2025.11.14.25340263

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