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Article

Ribosome recycling factor ABCE1 depletion inhibits nonsense-mediated mRNA decay by promoting stop codon readthrough

2019-12-10

Abstract excerpt

<h4>SUMMARY</h4> Nonsense-mediated mRNA decay (NMD) is an essential post-transcriptional surveillance pathway in vertebrates that appears to be mechanistically linked with translation termination. To gain more insight into this connection, we interfered with translation termination by depleting human cells of the ribosome recycling factor ABCE1, which resulted in an upregulation of many but not all endogenous NMD...

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Literature Corpus work
0f6e46dd-c3fb-5737-b86d-957557d833de
DOI
10.1101/870097
Open publication

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Ribosome recycling factor ABCE1 depletion inhibits nonsense-mediated mRNA decay by promoting stop codon readthroughDOI 10.1101/870097
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