Article
mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.
FEBS letters - 19 Jun 2007
Behm-Ansmant Isabelle, Kashima Isao, Rehwinkel Jan, Saulière Jérôme, Wittkopp Nadine, Izaurralde Elisa
Abstract excerpt
Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance pathway which ensures the rapid degradation of mRNAs containing premature translation termination codons (PTCs or nonsense codons), thereby preventing the accumulation of truncated and potentially harmful proteins. In this way, the NMD pathway contributes to suppressing or exacerbating the clinical manifestations of specific human genetic disorders....
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