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Article

Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants.

eLife - 22 Jul 2020

Serdar Lucas D, Whiteside DaJuan L, Nock Sarah L, McGrath David, Baker Kristian E

Abstract excerpt

Recognition and rapid degradation of mRNA harboring premature translation termination codons (PTCs) serves to protect cells from accumulating non-functional and potentially toxic truncated polypeptides. Targeting of PTC-containing transcripts is mediated by the nonsense-mediated mRNA decay (NMD) pathway and requires a conserved set of proteins including UPF1, an RNA helicase whose ATPase activity is essential for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32697194
DOI: 10.7554/eLife.57834
PMCID: PMC7375815

Genes

UPF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants.PMID 32697194Read ↗

ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons.Semantic proximity Read ↗

Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StorySemantic proximity Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

Ribosome recycling factor ABCE1 depletion inhibits nonsense-mediated mRNA decay by promoting stop codon readthroughSemantic proximity Read ↗

Upf1 stimulates degradation of the product derived from aberrant messenger RNA containing a specific nonsense mutation by the proteasome.Semantic proximity Read ↗

Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway.Semantic proximity Read ↗

Mechanism, factors, and physiological role of nonsense-mediated mRNA decay.Semantic proximity Read ↗

Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae.Semantic proximity Read ↗

An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decaySemantic proximity Read ↗

Position-Dependent NMD Generates Diverse Protein OutcomesSemantic proximity Read ↗

Suppression of premature termination codons as a therapeutic approach.Semantic proximity Read ↗

Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity.Semantic proximity Read ↗

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