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Article

Ataluren as an Agent for Therapeutic Nonsense Suppression

5 Dec 2012

Abstract excerpt

The interplay of translation and mRNA turnover has helped unveil how the regulation of gene expression is a continuum in which events that occur during the birth of a transcript in the nucleus can have profound effects on subsequent steps in the cytoplasm. Exemplifying this continuum is nonsense-mediated mRNA decay (NMD), the process wherein a premature stop codon affects both translation and mRNA decay. Studies...

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PMID: 23215857
DOI: 10.1146/annurev-med-120611-144851

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