Article
NMD: RNA biology meets human genetic medicine.
The Biochemical journal - 15 Sept 2010
Bhuvanagiri Madhuri, Schlitter Anna M, Hentze Matthias W, Kulozik Andreas E
Abstract excerpt
NMD (nonsense-mediated mRNA decay) belongs to the best-studied mRNA surveillance systems of the cell, limiting the synthesis of truncated and potentially harmful proteins on the one hand and playing an initially unexpected role in the regulation of global gene expression on the other hand. In the present review, we briefly discuss the factors involved in NMD, the different models proposed for the recognition of...
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