Article

Truncated RNA-binding protein production by DUX4-induced systemic inhibition of nonsense-mediated RNA decay

2021-06-30

Abstract excerpt

<h4>ABSTRACT</h4> Nonsense-mediated RNA decay (NMD) is a surveillance mechanism that degrades both canonical and aberrant transcripts carrying premature translation termination codons. NMD is thought to have evolved to prevent the synthesis of toxic truncated proteins. However, whether global inhibition of NMD results in widespread production of truncated proteins is unknown. A human genetic disease, facioscapulo...

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Literature Corpus work: f67d6fad-644f-5c47-a173-3f46cf40044d
DOI: 10.1101/2021.06.28.450189

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