Article

Cell type-resolved chromatin accessibility clocks for brain aging

2026-08-25

Abstract excerpt

Aging is a progressive decline in biological function that is proposed to be driven by the accumulation of epigenetic noise and the loss of epigenetic information. Among epigenetic readouts, DNA methylation has been extensively used to develop aging clocks, machine learning models that predict age from molecular data. However, DNA methylation clocks are relatively difficult to interpret and remain distant from gen...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: 0f698f00-7074-5b66-abb0-2615059b8c39
DOI: 10.64898/2026.08.22.746439

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Cell type-resolved chromatin accessibility clocks for brain agingDOI 10.64898/2026.08.22.746439Read

Human brain cell-type-specific aging clocks based on single-nuclei transcriptomicsSemantic proximity Read

Cell-type specific epigenetic clocks to quantify biological age at cell-type resolutionSemantic proximity Read

Early microglial priming in Alzheimer’s disease revealed by ME-seqSemantic proximity Read

A global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics and molecular signatures in the human and mouse brainsSemantic proximity Read

Single-cell machine learning uncovers genetically anchored, cell-type specific programs of Alzheimer’s diseaseSemantic proximity Read

Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci.Semantic proximity Read

DeepDynamics resolves cell-subtype and clinicopathological dynamics from bulk RNA-seq to identify mediators of Alzheimer’s disease riskSemantic proximity Read

Leveraging Single-Cell RNA-Seq to Generate Robust Microglia Aging ClocksSemantic proximity Read

Cell-type-specific transposable element demethylation and TAD remodeling in the aging mouse brainSemantic proximity Read

Epigenetic and 3D genome reprogramming during the aging of human hippocampusSemantic proximity Read

Spatial Dissection of the Distinct Cellular Responses to Normal Aging and Alzheimer’s Disease in Human Prefrontal Cortex at Single-Nucleus ResolutionSemantic proximity Read

An Epigenetic Signature of Vulnerable Neurons is Under Selective Pressure Associated with Longevity Across Placental Mammals.Semantic proximity Read