Article
Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci.
Epigenetics - 1 Dec 2024
Grodstein Francine, Lemos Bernardo, Yang Jingyun, de Paiva Lopes Katia, Vialle Ricardo A, Seyfried Nicholas, Wang Yanling, Shireby Gemma, Hannon Eilis, Thomas Alan, Brookes Keeley, Mill Jonathan, De Jager Philip L, Bennett David A
Abstract excerpt
The cortical epigenetic clock was developed in brain tissue as a biomarker of brain aging. As one way to identify mechanisms underlying aging, we conducted a GWAS of cortical age. We leveraged postmortem cortex tissue and genotyping array data from 694 participants of the Rush Memory and Aging Project and Religious Orders Study (ROSMAP; 11000,000 SNPs), and meta-analysed ROSMAP with 522 participants of Brains for...
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