Article

Leveraging Single-Cell RNA-Seq to Generate Robust Microglia Aging Clocks

2024-10-06

Abstract excerpt

‘Biological aging clocks’ - composite molecular markers thought to capture an individual’s biological age - have been traditionally developed through bulk-level analyses of mixed cells and tissues. However, recent evidence highlights the importance of gaining single-cell-level insights into the aging process. Microglia are key immune cells in the brain shown to adapt functionally in aging and disease. Recent studi...

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Literature Corpus work: 0ab92418-fd84-557e-a1b5-495da8da5dae
DOI: 10.1101/2024.10.05.616811

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