Article

Cell-type-specific transposable element demethylation and TAD remodeling in the aging mouse brain

2025-04-21

Abstract excerpt

Aging is a major risk factor for neurodegenerative diseases, yet underlying epigenetic mechanisms remain unclear. Here, we generated a comprehensive single-nucleus cell atlas of brain aging across multiple brain regions, comprising 132,551 single-cell methylomes and 72,666 joint chromatin conformation-methylome nuclei. Integration with companion transcriptomic and chromatin accessibility data yielded a cross-modal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be0183d7-07d4-53c4-b3a2-29cd4e35551d
DOI: 10.1101/2025.04.21.648266

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell-type-specific transposable element demethylation and TAD remodeling in the aging mouse brainDOI 10.1101/2025.04.21.648266Read

Single-cell Characterization of DNA Hydroxymethylation of the Mouse Brain During AgingSemantic proximity Read

Epigenomic complexity of the human brain revealed by single-cell DNA methylomes and 3D genome structuresSemantic proximity Read

An Integrative Single-Cell Epigenomic Atlas Annotates the Regulatory Genome of the Adult Mouse BrainSemantic proximity Read

A global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics and molecular signatures in the human and mouse brainsSemantic proximity Read

Single nucleus multi-omics links human cortical cell regulatory genome diversity to disease risk variantsSemantic proximity Read

Early microglial priming in Alzheimer’s disease revealed by ME-seqSemantic proximity Read

A comparative atlas of single-cell chromatin accessibility in the human brainSemantic proximity Read

Epigenetic and 3D genome reprogramming during the aging of human hippocampusSemantic proximity Read

Integrative single-cell analysis by transcriptional and epigenetic states in human adult brainSemantic proximity Read

Human Body Single-Cell Atlas of 3D Genome Organization and DNA MethylationSemantic proximity Read

A multimodal cell census and atlas of the mammalian primary motor cortexSemantic proximity Read

Brain Region-Specific Epigenomic Reorganization and Altered Cell States in Alzheimer’s DiseaseSemantic proximity Read