Article

Endothelial Cells retain inflammatory memory through chromatin remodeling

2025-06-17

Abstract excerpt

Sepsis survivors face a heightened risk of secondary infections and chronic vascular dysfunction despite clinical recovery, yet the underlying mechanisms remain poorly defined. Our study identifies a novel mechanism of endothelial inflammatory memory, wherein transient inflammatory exposure induces durable chromatin remodeling, priming endothelial cells for exaggerated responses to subsequent inflammatory insults....

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Literature Corpus work: 0f12e213-d315-5f36-aae9-e6df8d7ec83c
DOI: 10.1101/2025.06.12.659136

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