Article

Paraspeckles translate microbial insult-induced inflammation into neurovascular remodeling by enhancing CYR61-FGF2 signaling via RBM14 sequestration

2026-07-10

Abstract excerpt

<h4>Background</h4> Systemic inflammation triggered by microbial insults can disrupt endothelial homeostasis, impair blood-brain and blood-retinal barriers, leading to neurovascular remodeling in the central nervous system (CNS). Subnuclear condensates, paraspeckles, play a substantial role in stress-induced gene regulation, yet their contribution to the inflammatory relay from microbial insults to neurovascular...

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Literature Corpus work: 6078ae24-24e1-5c57-aa57-acab80381d74
DOI: 10.64898/2026.07.09.737621

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