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Altered DNA methylation underlies monocyte dysregulation and immune exhaustion memory in sepsis

1 Mar 2024

Abstract excerpt

Monocytes can develop an exhausted memory state characterized by reduced differentiation, pathogenic inflammation, and immune suppression that drives immune dysregulation during sepsis. Chromatin alterations, notably via histone modifications, underlie innate immune memory, but the contribution of DNA methylation remains poorly understood. Using an ex vivo sepsis model, we show altered DNA methylation throughout...

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PMID: 38442017
DOI: 10.1016/j.celrep.2024.113894

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