Article

Epigenetic Programming of Macrophage Phenotypes by STING–IRF3 Drives Inflammation in Ascending Thoracic Aortic Dissection

2026-01-25

Abstract excerpt

<h4>Background</h4> Ascending thoracic aortic dissection (ATAD) is characterized by extensive macrophage (MΦ) accumulation and profound inflammation; however, the mechanisms sustaining pro-inflammatory MΦ activation remain incompletely defined. Emerging evidence indicates that epigenetically generated immune memory drives innate immune cells toward persistent inflammatory states. In this study, we investigated wh...

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Literature Corpus work: 47294022-fa82-53c6-8244-edfe39895ef0
DOI: 10.64898/2026.01.22.701198

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