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Article

Sepsis Induces Specific Changes in Histone Modification Patterns in Human Monocytes

20 Mar 2015

Abstract excerpt

BACKGROUND: Sepsis is a global burden and the primary cause of death in intensive care units worldwide. The pathophysiological changes induced by the host's systemic inflammatory response to infection are not yet fully understood. During sepsis, the immune system is confronted with a variety of factors, which are integrated within the individual cells and result in changes of their basal state of responsiveness....

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PMID: 25793379
DOI: 10.1371/journal.pone.0121748

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