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Sepsis, immunosuppression and the role of epigenetic mechanisms

1 Feb 2021

Abstract excerpt

Introduction: Sepsis has pro- and anti-inflammatory processes caused by infectious agents. Sepsis survivors have impaired immune response due to immunosuppression. Gene expression during the inflammatory process is guided by transcriptional access to chromatin, with post-translational changes made in histones that determine whether the loci of the inflammatory gene are active, balanced, or suppressed. For this, a...

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PMID: 33596148
DOI: 10.1080/1744666x.2021.1875820

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