Article

SLAMF1-peptide mediated epigenetic priming reprograms innate immune responses in sepsis

2025-12-29

Abstract excerpt

Sepsis is characterized by profound immune dysregulation, including impaired innate immune responses and epigenetic reprogramming of monocytes. However, strategies to therapeutically restore immune function remain limited. Here, we identify a cell-penetrating peptide, P7-Pen, as a modulator of monocyte epigenetic state and inflammatory responsiveness. Using primary human monocytes and peripheral blood mononuclear...

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Literature Corpus work: 4d18ff8a-4eea-5371-9917-3aaf44a1ee67
DOI: 10.64898/2025.12.29.696918

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