Article

Sepsis Induces Age- and Sex-Specific Chromatin Remodeling in Myeloid-Derived Suppressor Cells

2025-05-30

Abstract excerpt

<h4>SUMMARY</h4> Sepsis survivors frequently develop long-term immune dysfunction, but the epigenetic mechanisms underlying persistent myeloid suppression remain unclear. Myeloid-derived suppressor cells (MDSCs), whose function is shaped by host age and sex, are key contributors to post-sepsis immune dysregulation. Here, we present a high-resolution epigenetic map targeting gene promoters of MDSCs after sepsis us...

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Literature Corpus work: c5df161a-cadf-5db0-a25f-fcf6b1b97bc8
DOI: 10.1101/2025.05.26.656229

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