Article

Epigenetic Locking of Vascular and Inflammatory Effectors Defines the Universal Host Response to Severe Infection

2026-01-13

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : Severe infections—whether bacterial (Tuberculosis), viral (Dengue), or polymicrobial (Sepsis)—converge on a shared phenotype of systemic inflammation and vascular dysfunction. While transcriptional signatures are well characterized, the epigenetic mechanisms predisposing immune cells to this pathological response remain undefined. <bold>Methods</bold> : We...

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Literature Corpus work: 951dbc04-4fc3-5409-b0f2-b2e39023f1ad
DOI: 10.21203/rs.3.rs-8572339/v1

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