Article

Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk

2025-06-20

Abstract excerpt

Chronic inflammation plays a central role in the progression of both infectious and vascular diseases, yet its impact on endothelial cells (ECs), which form the interface between blood and tissue, remains poorly understood. Given their constant exposure to inflammatory cytokines such as TNF-α and IFN-γ, we set out to investigate how cytokine induced inflammation shapes EC function at the molecular level. Using pri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da411f4b-5f16-506c-9066-f29f5458a076
DOI: 10.1101/2025.06.16.659872

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease riskDOI 10.1101/2025.06.16.659872Read

Endothelial Cells retain inflammatory memory through chromatin remodelingSemantic proximity Read

IFNγ, and to a Lesser Extent TNFα, Provokes a Sustained Endothelial Costimulatory Phenotype.Semantic proximity Read

Multi-omics delineation of cytokine-induced endothelial inflammatory statesSemantic proximity Read

Epigenetics and Trained Immunity.Semantic proximity Read

COVID-19 inactivated and non-replicating viral vector vaccines induce regulatory training phenotype in human monocytes under epigenetic control.Semantic proximity Read

OxLDL-mediated immunologic memory in endothelial cells.Semantic proximity Read

Endothelial Resolution of Inflammation is Delayed Following JAK-driven but not NFκB-dependent ActivationSemantic proximity Read

Innate Immune Memory is Stimulus SpecificSemantic proximity Read

Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression.Semantic proximity Read

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus InfectionSemantic proximity Read

The causes and consequences of trained immunity in myeloid cellsSemantic proximity Read

Trained immunity: adaptation within innate immune mechanismsSemantic proximity Read