Article

Altered DNA methylation underlies monocyte dysregulation and innate exhaustion memory in sepsis

2023-08-31

Abstract excerpt

<h4>ABSTRACT</h4> Innate immune memory is the process by which pathogen exposure elicits cell-intrinsic states to alter the strength of future immune challenges. Such altered memory states drive monocyte dysregulation during sepsis, promoting pathogenic behavior characterized by pro-inflammatory, immunosuppressive gene expression in concert with emergency hematopoiesis. Epigenetic changes, notably in the form of...

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Literature Corpus work: 1e7b61c7-8b57-50e4-a304-7972300678bb
DOI: 10.1101/2023.08.30.555580

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