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Dfm1 promotes Ste24-dependent translocon quality control

2026-07-02

Abstract excerpt

Proteins stalled during endoplasmic reticulum translocation clog Sec61 channels and require translocon quality control (TQC) mechanisms for clearance. Genetic screens implicated the derlin Dfm1 in TQC; however, its mechanistic role remained unclear. Using engineered and disease-relevant translocon-clogging substrates in Saccharomyces cerevisiae , we show Dfm1 functions in the Ste24-dependent branch of TQC, but no...

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Identifiers and source

Literature Corpus work
0ec6b573-9f64-58ba-b10f-7f6b204b6539
DOI
10.64898/2026.07.01.735875
Open publication

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Dfm1 promotes Ste24-dependent translocon quality controlDOI 10.64898/2026.07.01.735875
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