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Article

An intramembrane chaperone complex facilitates membrane protein biogenesis.

Nature - 1 Aug 2020

Chitwood Patrick J, Hegde Ramanujan S

Abstract excerpt

Integral membrane proteins are encoded by approximately 25% of all protein-coding genes1. In eukaryotes, the majority of membrane proteins are inserted, modified and folded at the endoplasmic reticulum (ER)2. Research over the past several decades has determined how membrane proteins are targeted to the ER and how individual transmembrane domains (TMDs) are inserted into the lipid bilayer3. By contrast, very...

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Identifiers

PMID: 32814900
DOI: 10.1038/s41586-020-2624-y
PMCID: PMC7610463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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