Article

A cargo receptor entrapment complex is a therapeutic node for genetically and clinically distinct proteinopathies

2026-07-13

Abstract excerpt

<h4>Summary</h4> Severe proteinopathies—such as retinitis pigmentosa, a form of inherited blindness—are driven by genetic mutations that overwhelm the quality control of the post-endoplasmic reticulum (post-ER) secretory pathway, causing toxic protein accumulation. Here, we identify a therapeutic node defined by a hetero-oligomeric cargo receptor complex consisting of TMED7, 2, 9, and 10. This “entrapment complex...

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Literature Corpus work: 61a5a661-b4eb-544a-aa44-ea3340863691
DOI: 10.64898/2026.07.10.737576

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