Article

ER-associated degradation relying on protein O-mannosylation

2025-01-15

Abstract excerpt

<h4>Summary</h4> Protein quality control in the secretory pathway, whose dysfunction is linked to various human diseases, begins in the endoplasmic reticulum (ER) and involves ER-associated degradation (ERAD) of terminally misfolded species. We have addressed the roles of protein O-mannosylation in ERAD using complementary genome-wide screens in yeast. Our findings reveal that protein O-mannosylation by the conse...

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Literature Corpus work: d708b489-2f08-5071-9d41-0954a310fc88
DOI: 10.1101/2025.01.15.633243

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