Article

Functional crosstalk between the carrier translocase machinery and YME1 complex maintains mitochondrial proteostasis and integrity

2022-02-03

Abstract excerpt

The TIM22 pathway cargos are essential for sustaining mitochondrial proteostasis as an excess of these proteins leads to proteostatic stress and cell death. Yme1 is an inner membrane metalloprotease that regulates proteostasis with its chaperone-like and proteolytic activities. Although the mitochondrial translocase and protease machinery are critical for organelle health, the functional link between these complex...

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Literature Corpus work: a0f2f874-6ac2-547d-b7f6-3e359c3b7a32
DOI: 10.1101/2022.02.03.478940

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