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Article

Interplay of substrate retention and export signals in endoplasmic reticulum quality control.

PloS one - 24 Nov 2010

Kawaguchi Shinichi, Hsu Chia-Ling, Ng Davis T W

Abstract excerpt

BACKGROUND: Endoplasmic reticulum (ER) quality control mechanisms are part of a comprehensive system to manage cell stress. The flux of molecules is monitored to retain folding intermediates and target misfolded molecules to ER-associated degradation (ERAD) pathways. The mechanisms of sorting remain unclear. While some proteins are retained statically, the classical model substrate CPY* is found in COPII...

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Identifiers

PMID: 21151492
DOI: 10.1371/journal.pone.0015532
PMCID: PMC2991357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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