Killer toxin K28 resistance in yeast relies on COG complex-mediated trafficking of the defence factor Ktd1.

doi:10.1242/jcs.263897

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Killer toxin K28 resistance in yeast relies on COG complex-mediated trafficking of the defence factor Ktd1.

Journal of cell science - 15 Jul 2025

Laidlaw Kamilla M E, Nadir Hatwan H, Milburn Amy, Xelhuantzi Martha S C, Stanislovas Justas, Droop Alastair P, MacDonald Sandy, Andreev Ilya, Leech Andrew, Ungar Daniel, Sadhu Meru J, MacDonald Chris

Abstract excerpt

AB toxins are a diverse family of protein toxins that enter host cells via endocytosis and induce cell death. In yeast, the AB toxin K28 is internalised to endosomes of susceptible yeast, before following the retrograde trafficking pathway and ultimately triggering cell cycle arrest. The endolysosomal defence factor Ktd1 protects against K28, but its regulation remains unclear. We show all lobe B subunits of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Endocytosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endosomes

Share to Golgi Apparatus

Share to Killer Factors, Yeast

Share to Protein Transport

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 40557545
DOI: 10.1242/jcs.263897
PMCID: PMC12301656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 13 Sept 2026.