Article
A cure for traffic jams: small molecule chaperones in the endoplasmic reticulum.
Traffic (Copenhagen, Denmark) - 1 Nov 2004
Römisch Karin
Abstract excerpt
Folding in the endoplasmic reticulum is the limiting step for the biogenesis of most secretory pathway cargo proteins; proteins which fail to fold are initially retained in the endoplasmic reticulum and subsequently often degraded. Mutations that affect secretory protein folding have profound phenotypes irrespective of their direct impact on protein function, because they prevent secretory proteins from reaching...
Topics
- Animals
- Endoplasmic Reticulum
- Humans
- Ions
- Ligands
- Models, Biological
- Molecular Chaperones
- Mutation
- Peptides
- Phenotype
- Protein Conformation
- Protein Folding