Article
Evasion of endoplasmic reticulum surveillance makes Wsc1p an obligate substrate of Golgi quality control.
Molecular biology of the cell - 1 Apr 2010
Wang Songyu, Ng Davis T W
Abstract excerpt
In the endoplasmic reticulum (ER), most newly synthesized proteins are retained by quality control mechanisms until folded. Misfolded molecules are sorted to ER-associated degradation (ERAD) pathways for disposal. Reports of mutant proteins degraded in the vacuole/lysosome suggested an independent Golgi-based mechanism also at work. Although little is understood of the post-ER pathway, the growing number of...
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