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Article

Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates.

Cell reports - 19 Oct 2021

Nejatfard Anahita, Wauer Nicholas, Bhaduri Satarupa, Conn Adam, Gourkanti Saroj, Singh Narinderbir, Kuo Tiffany, Kandel Rachel, Amaro Rommie E, Neal Sonya E

Abstract excerpt

Nearly one-third of proteins are initially targeted to the endoplasmic reticulum (ER) membrane, where they are correctly folded and then delivered to their final cellular destinations. To prevent the accumulation of misfolded membrane proteins, ER-associated degradation (ERAD) moves these clients from the ER membrane to the cytosol, a process known as retrotranslocation. Our recent work in Saccharomyces...

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Identifiers

PMID: 34686332
DOI: 10.1016/j.celrep.2021.109840
PMCID: PMC8641752

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