Article
A striking quality control subcompartment in Saccharomyces cerevisiae: the endoplasmic reticulum-associated compartment.
Molecular biology of the cell - 1 Feb 2004
Huyer Gregory, Longsworth Gaby L, Mason Deborah L, Mallampalli Monica P, McCaffery J Michael, Wright Robin L, Michaelis Susan
Abstract excerpt
The folding of nascent secretory and membrane proteins is monitored by the endoplasmic reticulum (ER) quality control system. Misfolded proteins are retained in the ER and can be removed by ER-associated degradation. As a model for the ER quality control of multispanning membrane proteins in yeast, we have been studying mutant forms of Ste6p. Here, we identify mislocalized mutant forms of Ste6p that induce the...
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