Article

Derlin-mediated ERAD of lipid regulator ORMDL3 safeguards mitochondrial function

2026-03-03

Abstract excerpt

Mammalian Derlin proteins (Derlin-1, Derlin-2, and Derlin-3) are conserved components of the endoplasmic reticulum–associated degradation (ERAD) machinery that mediate the retrotranslocation and proteasomal degradation of misfolded ER-resident proteins. However, their paralog-specific contributions to cellular homeostasis remain poorly understood. Here, we show that Derlin deficiency disrupts mitochondrial archite...

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Literature Corpus work: 149ead67-87e5-544f-a2d8-de8b2a045aeb
DOI: 10.64898/2026.02.27.708653

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