Article

The lateral entorhinal cortex is a hub for local and global dysfunction in pre-tauopathy states

2020-04-04

Abstract excerpt

Functional network activity alterations are one of the earliest hallmarks of Alzheimer’s disease (AD), detected prior to amyloidosis and tauopathy. Better understanding the neuronal underpinnings of such network alterations could offer mechanistic insight into AD progression. Here, we examined a mouse model (early-tauopathy 3xTgAD mice) recapitulating this early AD stage. We found resting functional connectivity l...

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Identifiers and source

Literature Corpus work: 0ebcb315-dc89-589c-8d65-ccc79f0f7097
DOI: 10.1101/2020.04.03.022590

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