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Article

Early alterations in functional connectivity and white matter structure in a transgenic mouse model of cerebral amyloidosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Oct 2014

Grandjean Joanes, Schroeter Aileen, He Pan, Tanadini Matteo, Keist Ruth, Krstic Dimitrije, Konietzko Uwe, Klohs Jan, Nitsch Roger M, Rudin Markus

Abstract excerpt

Impairment of brain functional connectivity (FC) is thought to be an early event occurring in diseases with cerebral amyloidosis, such as Alzheimer's disease. Regions sustaining altered functional networks have been shown to colocalize with regions marked with amyloid plaques burden suggesting a strong link between FC and amyloidosis. Whether the decline in FC precedes amyloid plaque deposition or is a...

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Identifiers

PMID: 25297104
DOI: 10.1523/JNEUROSCI.4762-13.2014
PMCID: PMC6608375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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