Article
Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants.
Neurobiology of aging - 1 Oct 2015
Lehmann Manja, Madison Cindee, Ghosh Pia M, Miller Zachary A, Greicius Michael D, Kramer Joel H, Coppola Giovanni, Miller Bruce L, Jagust William J, Gorno-Tempini Maria L, Seeley William W, Rabinovici Gil D
Abstract excerpt
The common and specific involvement of brain networks in clinical variants of Alzheimer's disease (AD) is not well understood. We performed task-free ("resting-state") functional imaging in 60 nonfamilial AD patients, including 20 early-onset AD (age at onset <65 years, amnestic/dysexecutive deficits), 24 logopenic aphasia (language deficits), and 16 posterior cortical atrophy patients (visual deficits), as well...
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