Article
Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.
Nature neuroscience - 1 Feb 2014
Khan Usman A, Liu Li, Provenzano Frank A, Berman Diego E, Profaci Caterina P, Sloan Richard, Mayeux Richard, Duff Karen E, Small Scott A
Abstract excerpt
The entorhinal cortex has been implicated in the early stages of Alzheimer's disease, which is characterized by changes in the tau protein and in the cleaved fragments of the amyloid precursor protein (APP). We used a high-resolution functional magnetic resonance imaging (fMRI) variant that can map metabolic defects in patients and mouse models to address basic questions about entorhinal cortex pathophysiology....
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