Article

Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8)

2024-06-20

Abstract excerpt

Spinocerebellar Ataxia Type 8 (SCA8) is an inherited neurodegenerative disease caused by a bidirectionally expressed CTG●CAG expansion mutation in the ATXN-8 and ATXN8-OS genes. While primarily a motor disorder, psychiatric and cognitive symptoms have been reported. It is difficult to elucidate how the disease alters brain function in areas with little or no degeneration producing both motor and cognitive symptoms...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68ecfc97-2de8-565d-b87c-563d2dc8e387
DOI: 10.1101/2024.06.20.599947

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8)DOI 10.1101/2024.06.20.599947Read

Time-Resolved Neuronal Network Dynamics Distinguish Pathological States in Organoid ModelsSemantic proximity Read

Hemodynamic Signals Reshape Biological Inference in Widefield Calcium ImagingSemantic proximity Read

Brain digital twins reveal network changes in congenital and slowly progressive cerebellar ataxiasSemantic proximity Read

Endogenous pathology in tauopathy mice progresses via brain networksSemantic proximity Read

Graph Theory Identifies Autistic Patterns in the Prefrontal Circuit of a Mouse Model of AutismSemantic proximity Read

Large-scale topology and the default mode network in the mouse connectomeSemantic proximity Read

Disrupted cerebellar structural connectome in spinocerebellar ataxia type 3 and its association with transcriptional profilesSemantic proximity Read

The landscape of functional brain network impairments in late-onset GM2 gangliosidosisSemantic proximity Read

Disrupted cerebellar structural connectome in spinocerebellar ataxia type 3 and its association with transcriptional profilesSemantic proximity Read

White matter dysfunction in Alzheimer’s disease is associated with disease-related transcriptomic signaturesSemantic proximity Read

Structure-Function Coupling Aligns with a Unimodal-to-Transmodal Gradient in the Mouse CortexSemantic proximity Read

High-definition Brain Network (HDBN) Delineation of CDKL5 Deficiency Disorder (CDD) in Genetically Engineered MiceSemantic proximity Read