Article

Resting-state functional dynamics alterations relate to plasma amyloid markers and explain memory impairments in the TgF344-AD model of Alzheimer’s disease

2025-06-03

Abstract excerpt

Resting-state (RS) fMRI studies of Alzheimer’s disease’s (AD) impact on brain function commonly use functional connectivity (FC), ignoring short-timescale network dynamics, captured by co-activation patterns (CAPs), shown to accurately classify transgenic rodents from the wild-type (WT). We acquired high temporal resolution RS-fMRI data in the TgF344-AD rat model at pre-plaque and plaque stages and delineated brai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ca83913-44a1-59bc-ac68-aa74b452fc87
DOI: 10.1101/2025.06.01.657264

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Resting-state functional dynamics alterations relate to plasma amyloid markers and explain memory impairments in the TgF344-AD model of Alzheimer’s diseaseDOI 10.1101/2025.06.01.657264Read

Long-term dietary interventions fail to mitigate functional connectivity loss and cognitive decline in the TgF344-AD rat model of Alzheimer’s DiseaseSemantic proximity Read

Multimodal Fusion Analysis of [18F]Florbetapir PET and Multiscale Functional Network Connectivity in Alzheimer’s DiseaseSemantic proximity Read

Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities.Semantic proximity Read

Accelerated functional brain aging in pre-clinical familial Alzheimer's disease.Semantic proximity Read

Differential effects of aging, Alzheimer’s pathology, and <i>APOE4</i> on longitudinal functional connectivity and episodic memory in older adultsSemantic proximity Read

Alzheimer’s risk markers and resting-state dynamic functional connectivity: Cross-Sectional Findings from the AGUEDA StudySemantic proximity Read

Connectome-based predictive modeling of brain pathology and cognition in Autosomal Dominant Alzheimer’s DiseaseSemantic proximity Read

APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of AgingSemantic proximity Read

Brain network fingerprints of Alzheimer's disease risk factors in mouse models with humanized APOE alleles.Semantic proximity Read

Neural mechanisms of disease pathology and cognition in young-onset Alzheimer’s Disease variantsSemantic proximity Read

Early alterations in functional connectivity and white matter structure in a transgenic mouse model of cerebral amyloidosis.Semantic proximity Read

Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease.Semantic proximity Read