Article

Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis

2019-08-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Alzheimer’s disease (AD) is the most common form of dementia in the elderly population. Currently, no effective cure is available for AD. According to the amyloid hypothesis, the accumulation and deposition of the amyloid-beta (Aβ) peptides plays a key role in AD pathology. Soluble Aβ (sAβ) oligomers were shown to be synaptotoxic and involved in pathological hypersynchronisa...

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Literature Corpus work: 5529a29d-ea5b-5211-ae82-d4dfa76b896e
DOI: 10.1101/723981

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