Article

Resting-State fMRI reveals Longitudinal Alterations in Brain Network Connectivity in a Mouse Model of Huntington’s Disease

2022-11-21

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease is an autosomal, dominantly inherited neurodegenerative disease caused by an expansion of the CAG repeats in exon 1 of the huntingtin gene. Neuronal degeneration and dysfunction that precedes regional atrophy result in the impairment of striatal and cortical circuits that affect the brain’s large-scale network functionality. However, the evolution of these disease-driven, la...

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Literature Corpus work: 4238264f-f1ed-53e6-ade6-dc27eb5205ee
DOI: 10.1101/2022.11.19.517166

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