Article

The fork restart factor PHF6 interacts with RRM2 and binds to H3K56ac marked nascent DNA

2023-03-10

Abstract excerpt

The PHF6 protein is a presumed chromatin reader implicated in disease through germline loss-of-function mutations causing cognitive disability syndromes and somatic mutations are predominantly observed in acute T-cell leukemia. Previous reports support a role for PHF6 in DNA damage repair, replication fork restart as well as hematopoietic precursor cell self-renewal capacity and lineage commitment. To explore bett...

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Literature Corpus work: 0eba9b95-1a7d-5109-b7d5-72a568ff8a8f
DOI: 10.1101/2023.03.08.531704

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