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Article

PHF6 Interacts with the Nucleosome Remodeling and Deacetylation (NuRD) Complex

21 Jun 2012

Abstract excerpt

Mutations in PHF6 are the cause of Börjeson-Forssman-Lehman syndrome (BFLS), an X-linked intellectual disability (XLID) disorder, and both T-cell acute lymphoblastic leukemia (T-ALL) and acute myeloid leukemia (AML). The PHF6 gene encodes a protein with two plant homeodomain (PHD)-like zinc finger domains. As many PHD-like domains function to target chromatin remodelers to post-translationally modified histones,...

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PMID: 22720776
DOI: 10.1021/pr3004369

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PHF6 Interacts with the Nucleosome Remodeling and Deacetylation (NuRD) ComplexPMID 22720776Read ↗

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The fork restart factor PHF6 interacts with RRM2 and binds to H3K56ac marked nascent DNASemantic proximity Read ↗

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