Article
Phf6 truncating mutation drives leukemogenesis via disrupted epigenetic regulation in mice.
Leukemia - 1 Mar 2026
Guo Ying, Sui Pinpin, Yang Hui, Zhu Ganqian, Li Ying, Chen Shi, Zhao Yuehui, Ge Guo, Eisa Yusra A, Delma Caroline R, Medina Edward A, Zhang Peng, Lee Jihoon, Xu Mingjiang, Yang Feng-Chun
Abstract excerpt
Somatic mutations in PHF6 (PHD finger protein 6) are common in hematologic malignancies and confer worse overall survival in acute myeloid leukemia patients. These mutations are predominantly frameshift or nonsense variants, resulting in a truncated PHF6 protein. However, the specific role of truncated PHF6 in leukemogenesis remains unclear. Here, we generated a transgenic mouse model, Phf6R274XTg, expressing a...
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