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Article

PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.

Genes & development - 15 May 2017

Soto-Feliciano Yadira M, Bartlebaugh Jordan M E, Liu Yunpeng, Sánchez-Rivera Francisco J, Bhutkar Arjun, Weintraub Abraham S, Buenrostro Jason D, Cheng Christine S, Regev Aviv, Jacks Tyler E, Young Richard A, Hemann Michael T

Abstract excerpt

Developmental and lineage plasticity have been observed in numerous malignancies and have been correlated with tumor progression and drug resistance. However, little is known about the molecular mechanisms that enable such plasticity to occur. Here, we describe the function of the plant homeodomain finger protein 6 (PHF6) in leukemia and define its role in regulating chromatin accessibility to lineage-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28607179
DOI: 10.1101/gad.295857.117
PMCID: PMC5495126

Genes

PHF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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