Article

Repetitive DNA-resolved epigenomics maps chromatin rewiring during aging and malignant transformation

2026-05-01

Abstract excerpt

Repetitive DNA constitutes more than half of the human genome, yet its chromatin landscape remains poorly understood. Here, we integrated multi-mapping reads across 3, 744 repeat subfamilies and 937 ChIP-seq experiments for six canonical histone marks in hematopoietic cells and chronic malignancies from the BLUEPRINT consortium. Chromatin signals at repeats encode cell type-specific signatures, with certain elemen...

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Literature Corpus work: 5fe82879-582c-59e9-a74a-d8c493878b58
DOI: 10.64898/2026.04.29.721644

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