Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PHF6 Mutations in Hematologic Malignancies

26 Jul 2021

Abstract excerpt

Next generation sequencing has uncovered several genes with associated mutations in hematologic malignancies that can serve as potential biomarkers of disease. Keeping abreast of these genes is therefore of paramount importance in the field of hematology. This review focuses on PHF6, a highly conserved epigenetic transcriptional regulator that is important for neurodevelopment and hematopoiesis. PHF6 serves as a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Acute Myeloid Leukemia Research
Share to Chronic Myeloid Leukemia Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34381727
DOI: 10.3389/fonc.2021.704471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PHF6 Mutations in Hematologic MalignanciesPMID 34381727Read ↗

Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting.Semantic proximity Read ↗

PHF6 mutations in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Phf6 truncating mutation drives leukemogenesis via disrupted epigenetic regulation in mice.Semantic proximity Read ↗

PHF6 mutations in T-lineage acute lymphoblastic leukemia.Semantic proximity Read ↗

PHF6 mutations in adult acute myeloid leukemia.Semantic proximity Read ↗

PHF6 mutations in myelodysplastic syndromes, chronic myelomonocytic leukemia and acute myeloid leukemiaSemantic proximity Read ↗

PHF6 mutations in chronic myelomonocytic leukemia identify a unique subset of patients with distinct phenotype and superior prognosis.Semantic proximity Read ↗

PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.Semantic proximity Read ↗

Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentialsSemantic proximity Read ↗

Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemnessSemantic proximity Read ↗

Clinical Characteristics, Gene Mutation Profiles and Prognosis of Patients With Acute Myeloid Leukemia Carrying PHF6 Mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.